As Ho Chi Minh City evolves into a megacity, the demand for social housing is increasing rapidly, creating an urgent need for sustainable urban spatial development and improved accessibility to public transportation systems. However, current social housing development is primarily driven by land availability and investment conditions, with limited integration into mass public transit systems. This has resulted in an uneven spatial distribution of social housing, increased commuting costs, and reduced efficiency in the utilization of urban infrastructure. Based on a review of theories on transit-oriented development (TOD), an analysis of Ho Chi Minh City's urban spatial structure, and lessons drawn from the Paris metropolitan region, this study proposes a strategic framework for integrating social housing development with mass public transit systems. The findings establish key principles for site selection, spatial organization, and the distribution of social housing along major public transit corridors and transit hubs. Furthermore, the study recommends an integrated approach linking housing planning, land-use planning, and transportation development. The proposed framework contributes to strengthening the scientific basis for formulating social housing policies in the context of Ho Chi Minh City's transformation into a megacity. It also promotes more efficient land use, enhances access to employment opportunities and urban services, and supports sustainable urban development.